Cytostatic Activity of Some Phenolic Acids of Scrophularia frutescens L. var. frutescens
نویسندگان
چکیده
M. D. Garcia, M. C. Ahumada and M. T. Saenz Departamento de Farmacologfa, Facultad de Farmacia, c/Profesor Garcia Gonzalez s/n, 41012 Sevilla, Spain Z. Naturforsch. 53c, 1093-1095 (1998); received April 8/October 7, 1998 Scrophularia frutescens. Cultured H ep-2 Cells, Cultured McCoy Cells, Phenolic Acids The cytostatic activity of seven phenolic acids: coumaric, caffeic, ferulic, gentisic, protocatechuic, syringic and isovanillic acid previously isolated from Scrophularia frutescens has been evaluated against H ep -2 cells (de rived from a human epidermoid carcinoma of the lar ynx) and McCoy cells (derived from the synovial fluid in the knee joint of a patient suffering from degenerative arthritis). The compounds belonging to the cinnamic group present the highest activity.
منابع مشابه
Phytochemical study of polyphenols in Perilla Frutescens as an antioxidant
Perilla frutescens is an annual herb of the mint family native to East Asia. Polyphenols present in perilla have various structural varieties with large diversity of biological activities. It is direct influence the quality of perilla plant and their potential functions. Some of these products have been studied and proven to be effective source of phenolic antioxidants. The aqueous extract cont...
متن کاملAnti-inflammatory Effect of Perilla frutescens (L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages
This study was designed to investigate the inhibitory effects of Perilla frutescens (L.) Britton var. frutescens extract on the production of inflammation-related mediators (NO, ROS, NF-κB, iNOS and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Perilla frutescents (L.) Britton var. frutescens was air-dried and extracted with e...
متن کاملOptimization of Antibacterial Activity of Perilla frutescens var. acuta Leaf against Staphylococcus aureus Using Evolutionary Operation Factorial Design Technique
This study was undertaken to optimize extraction using evolutionary operation-factorial (EVOP) design technique to elicit the antibacterial activity of Perilla frutescens var. acuta leaf against Staphylococcus aureus ATCC6538. Higher antibacterial activity was achieved at higher extraction temperature and over a longer extraction time. Antibacterial activity was not affected by differentiation ...
متن کاملOptimization of Antibacterial Activity of Perilla frutescens var. acuta Leaf against Pseudomonas aeruginosa Using the Evolutionary Operation-Factorial Design Technique
This study was undertaken to optimize the conditions for the extraction of antibacterial activity of Perilla frutescens var. acuta leaf against Pseudomonas aeruginosa KCTC 2004 using the evolutionary operation-factorial (EVOP) design technique. Increased antibacterial activity was achieved at higher extraction temperatures and with a longer extraction time. Antibacterial activity was not affect...
متن کاملPhytochemical study of polyphenols in Perilla Frutescens as an antioxidant
Perilla frutescens is an annual herb of the mint family native to East Asia. Polyphenols present in perilla have various structural varieties with large diversity of biological activities. It is direct influence the quality of perilla plant and their potential functions. Some of these products have been studied and proven to be effective source of phenolic antioxidants. The aqueous extract cont...
متن کامل